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Determining the appropriate insulin dose adjustments can also be difficult, causing more lows and variability

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Patients should be counseled to contact their healthcare provider if they experience any of the following: Severe or persistent gastrointestinal symptoms including intractable nausea or vomiting lasting more than 24-48 hours, inability to maintain adequate oral hydration, severe abdominal pain (particularly if localized to the upper abdomen or radiating to the back), or signs of gastrointestinal bleeding such as bloody or black stools

Lawsuits have also claimed that Novo Nordisks other GLP-1 products (like Saxenda, a liraglutide drug) may have caused patients to suffer from gastroparesis and other serious gastrointestinal conditions